Completed puzzles (34)
Puzzle PZ18
Description
Zika virus.
RNA sequence (5' to 3')
GGGUCAGGCCGGCGAAAGUCGCCACAGUUUGGGGAAAGCUGUGCAGCCUG UAACCCCCCCACGAAAGUGGG
Experimental structure(s)
solutionPZ18.pdb
References

B. M. Akiyama, H. M. Laurence, A. R. Massey, D. A. Costantino, X. Xie, Y. Yang, P. Y. Shi, J. C. Nix, J. D. Beckham and J. S. Kieft (2016) Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease. Science 354: 1148-1152

PDB ID:
5tpy
Opening date:
24 Oct 2016, 22:24
Closing date (Human category):
10 Nov 2016, 23:24
Closing date (Webserver category):
26 Oct 2016, 23:24
Puzzle PZ17
Description
Pistol ribozyme.
RNA sequence (5' to 3')
CGUGGUUAGGGCCACGUUAAAUAGUUGCUUAAGCCCUAAGCGUUGAUAAA UAUCAGGUGCAA
Experimental structure(s)
solutionPZ17.pdb solutionPZ17_1.pdb solutionPZ17_2.pdb
References

A. Ren, N. Vušurović, J. Gebetsberger, P. Gao, M. Juen, C. Kreutz, R. Micura and D. J. Patel (2016) Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage. Nature Chemical Biology, 12: 702–708

PDB ID:
5k7c
Opening date:
06 Jun 2016, 23:24
Closing date (Human category):
05 Jul 2016, 23:24
Closing date (Webserver category):
08 Jun 2016, 23:24
Puzzle PZ15
Description
Hammerhead Ribozyme. Predict as 2 chains.
RNA sequence (5' to 3')
GGGUACUUAAGCCCACUGAUGAGUCGCUGGGAUGCGACGAAACGCCCA- GGGCGUCUGGGCAGUACCCA
Experimental structure(s)
solutionPZ15.pdb
References

A. Mir and B. L. Golden (2016) Two Active Site Divalent Ions in the Crystal Structure of the Hammerhead Ribozyme Bound to a Transition State Analogue. Biochemistry 55(4): 633–636

PDB ID:
5di4
Opening date:
31 Aug 2015, 23:24
Closing date (Human category):
30 Sep 2015, 23:24
Closing date (Webserver category):
02 Sep 2015, 23:24
Puzzle PZ14Bound
Description
L-glutamine riboswitch. Predict Bound forms.
RNA sequence (5' to 3')
CGUUGACCCAGGAAACUGGGCGGAAGUAAGGCCCAUUGCACUCCGGGCCUGAAG CAACGCG
Experimental structure(s)
solutionPZ14Bound.pdb solutionPZ14Bound_1.pdb solutionPZ14Bound_2.pdb solutionPZ14Bound_3.pdb solutionPZ14Bound_4.pdb solutionPZ14Bound_5.pdb
References

A. Ren, Y. Xue, A. Peselis, A. Serganov, H. M. Al-Hashimi and D. J. Patel (2015) Structural and Dynamic Basis for Low-Affinity, High- Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Rep. 13(9): 1800-1813

PDB ID:
5ddo
Opening date:
01 Aug 2015, 23:24
Closing date (Human category):
31 Aug 2015, 23:24
Puzzle PZ14Free
Description
L-glutamine riboswitch. Predict Free forms.
RNA sequence (5' to 3')
CGUUGGCCCAGGAAACUGGGUGGAAGUAAGGCCCAUUGCACUCCGGGCCUGAAG CAACGCU
Experimental structure(s)
solutionPZ14Free.pdb solutionPZ14Free_1.pdb
References

A. Ren, Y. Xue, A. Peselis, A. Serganov, H. M. Al-Hashimi and D. J. Patel (2015) Structural and Dynamic Basis for Low-Affinity, High- Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Rep. 13(9): 1800-1813

PDB ID:
5ddo
Opening date:
01 Aug 2015, 23:24
Closing date (Human category):
31 Aug 2015, 23:24